D-ORB

The Overrepresented RNA Blocks

M.J. Dupont, F. Major

D-ORB: A Web Server to Extract Structural Features of Related But Unaligned RNA Sequences

J. Mol. Biol., 435 (2023)

H19 conserved region 1 (Rfam: RF01972)

Options

Negatives sequences: Random sequences of similar lengths
ORBs positions sequence: Best consensus structure-matching sequence
Motifs: 162,498 motifs on the alphabet ACGURYN

Rfam

D-ORB

Augmented

C(CC)N
A(UC)N
G(CY(C))
R(R(G))
((C)U)C

100.0
100.0
94.7
100.0
100.0

C(CC)N
A(UC)N
G(CY(C))
R(R(G))
((C)U)C

% of positive sequence with ORB

Job*

Email*

Sequence(s)*

Obtain

One structure matching the consensus structure ORBs
Several structures containing instances of most discriminative ORBs

Up to structures per sequence

Position offset nucleotides

Job*

Email*

Wildtype sequence*

Mutant sequences

All SNPs
Submit mutant sequences

Use the mutation generator

Deep neural network:

5-fold cross-validation: 99.9 %
(± 0.0818 %)

Decision tree:

5-fold cross-validation: 95.9 %
(± 6.63 %)

D-ORB structure

D-ORB structure decision tree:

5-fold cross-validation: 91.5 %
(± 7.11 %)

of AF190058.1/714-646

AF190058.1/714-646

GAGGCACCGAUCCCGGUCCGCCGCCGCCCGCGAGGCCCACCUUGGCCACGGCUCUGGAGGCCAGUGCCU
(.((((((((..)))(((....)))(..((((((((..)))))((((..))).)..)).))..))))))
.........1.........2.........3.........4.........5.........6.........
123456789012345678901234567890123456789012345678901234567890123456789

abstract shape: `(()(()()))`

					Number of sequences
	Structure	ORBs			(out of 19)	(%)
1		C(CC)N			19	100.0
>AF190057.1/799-729 GAGGCACCGAUCCCUGCUCCGUCGACGCCCGCAGAGGCCCGCCUUGGCCCGGGCUCUGGAGGCCAGUGCCU .....................................(..).............................. >AAKN02038607.1/34760-34690 GAGGCACCGAUCACUGCUCCGUCGUCACCUGCGAGGCCCACCUUGGCCACAGGCUCUGGAGGCCAGUGCCU ....................................(..)............................... >BC053636.1/935-865 GAGGCACCGAUCCCGGCUCCGUCGCCGCCCGCGAGGCCCGCCUUGGCCACGGGCUCUGGAGGCCAGUGCCU ....................................(..)............................... >AF190056.1/755-685 GAGGCACCGAUCCCUGCUCCGUCGUCGCCCGCGGAGCCCACCUCGGCCACGGGCUCUGGAGGCCAGCGCCC ...........................(..)........................................ >AY849926.1/1117-1048 GAGGCACCGAUCCCGCUCCGUCAUCGCCCGCAGAGGCCCGCCUUGGCCACGAGCUCGAAGUCCAAUGCCC ....................................(..).............................. >AJ566210.1/5618-5549 AAGGCACCGAUCCCGCUCCGUCAUCGCCCGCAGAGGCCCGCCUUGGCCACGGGCUCGAAGUCCAGUGCCC ...........(..)....................................................... >AAWR02038016.1/7406-7476 GAGGCACCGAUCACUGCUCCAUCGCCGCCCGCACAGGCCCGCCUUGGCCGCGGGCUCCGGAGUCCAGGCCC .....................................(..).............................. >AAYZ01478517.1/931-1000 AGGGCGCCGAUCUCGCUCCAUCGCAGCCCAUCAGGCCCACCUUGGCCACGGGCUCAGGAAGCCAGCGCCC ...................................(..)............................... >ACBE01354129.1/1652-1723 GAGGCACCGAUCCCUGCUCCGUCGUCGCCCGCAGAGGCCCACCUUGGCCACGGGCUCCGGAGGCCAGUGCCC ...........................(..)......................................... >AAPY01607917.1/1901-1971 GAGGCACCGAUCACUGCUCCGUCGCUGCCCACGAGGCCCUCCUUGGCCAUGGGCUCUGGAGGCCAGUGCCC ....................................(..)............................... >AY091484.1/1481-1411 AAGGCACCGAUCCCGCUCCGUCAUCGCCCAGCAGAGGCCCGCCUUGGCCACGGGCUCGAAGUCCAGUGCCC ...........(..)........................................................ >AF190058.1/714-646 GAGGCACCGAUCCCGGUCCGCCGCCGCCCGCGAGGCCCACCUUGGCCACGGCUCUGGAGGCCAGUGCCU ...........(..)...................................................... >BC009853.1/63-1 GAGGCACCGAUCCCGGCUCCGUCGCCGCCCGCGAGGCCCGCCUUGGCCACGGGCCCUCGUGCC ....................................(..)....................... >M97348.1/880-810 GAGGCGCCGAUCACUGCUCCGUCGCCGCCCGCAAGGCCCGCCUUGGCCGCGGGCUCUGGAGGCCAGCGCCC ....................................(..)............................... >ABRN01220595.1/5512-5580 CGGACCGAUCCAUGCUCCGUCACCGCCCGCAGAGGCCCGCCUUGGCCAUGGGCUCGGAGGCCAGUGACC ...................................(..).............................. >X07201.1/1693-1625 GAGUCACCGAUCACUGCUCCGUCGCCGCCCGCAAGCCUCCUUGGCCACGGACUCUGGAGGCCAGUGCCU ...........................(..)...................................... >BC025150.1/163-93 GAGACACCGAUCACUGCUCCGUCGCCGCCCGCAAGGCCCUCCUUGGCCACGGACUCUGGAGGCCAGUGCCU ....................................(..)............................... >AF214115.1/1092-1022 GAGGCACCGAUCACUGCUCCGUCGCCGCCCGCAAGGCCCUCCUUGGCCACGGACUCUGGAGGCCAGUGCCU ....................................(..)............................... >ABRP01221690.1/1794-1865 GAGGCACCGAUCCCUGCUCCGUCACCGCCCGCGCUGGCCCGCCUUGGCCACGGGCUCCGGAGGCCAGUGCCC ...........................(..).........................................
2		C(CC)N A(UC)N			19	100.0
>ACBE01354129.1/1652-1723 GAGGCACCGAUCCCUGCUCCGUCGUCGCCCGCAGAGGCCCACCUUGGCCACGGGCUCCGGAGGCCAGUGCCC .........(..)..............(..)......................................... >AF190056.1/755-685 GAGGCACCGAUCCCUGCUCCGUCGUCGCCCGCGGAGCCCACCUCGGCCACGGGCUCUGGAGGCCAGCGCCC .........(..)..............(..)........................................ >AAKN02038607.1/34760-34690 GAGGCACCGAUCACUGCUCCGUCGUCACCUGCGAGGCCCACCUUGGCCACAGGCUCUGGAGGCCAGUGCCU .........(..).......................(..)............................... >AAPY01607917.1/1901-1971 GAGGCACCGAUCACUGCUCCGUCGCUGCCCACGAGGCCCUCCUUGGCCAUGGGCUCUGGAGGCCAGUGCCC .........(..).......................(..)............................... >AAWR02038016.1/7406-7476 GAGGCACCGAUCACUGCUCCAUCGCCGCCCGCACAGGCCCGCCUUGGCCGCGGGCUCCGGAGUCCAGGCCC .........(..)........................(..).............................. >BC053636.1/935-865 GAGGCACCGAUCCCGGCUCCGUCGCCGCCCGCGAGGCCCGCCUUGGCCACGGGCUCUGGAGGCCAGUGCCU .........(..).......................(..)............................... >AY091484.1/1481-1411 AAGGCACCGAUCCCGCUCCGUCAUCGCCCAGCAGAGGCCCGCCUUGGCCACGGGCUCGAAGUCCAGUGCCC .........(..)........................(..).............................. >ABRN01220595.1/5512-5580 CGGACCGAUCCAUGCUCCGUCACCGCCCGCAGAGGCCCGCCUUGGCCAUGGGCUCGGAGGCCAGUGACC .......(..)........................(..).............................. >AAYZ01478517.1/931-1000 AGGGCGCCGAUCUCGCUCCAUCGCAGCCCAUCAGGCCCACCUUGGCCACGGGCUCAGGAAGCCAGCGCCC .........(..)......................(..)............................... >X07201.1/1693-1625 GAGUCACCGAUCACUGCUCCGUCGCCGCCCGCAAGCCUCCUUGGCCACGGACUCUGGAGGCCAGUGCCU .........(..)..............(..)...................................... >AY849926.1/1117-1048 GAGGCACCGAUCCCGCUCCGUCAUCGCCCGCAGAGGCCCGCCUUGGCCACGAGCUCGAAGUCCAAUGCCC .........(..).......................(..).............................. >BC025150.1/163-93 GAGACACCGAUCACUGCUCCGUCGCCGCCCGCAAGGCCCUCCUUGGCCACGGACUCUGGAGGCCAGUGCCU .........(..).......................(..)............................... >AF214115.1/1092-1022 GAGGCACCGAUCACUGCUCCGUCGCCGCCCGCAAGGCCCUCCUUGGCCACGGACUCUGGAGGCCAGUGCCU .........(..).......................(..)............................... >AF190057.1/799-729 GAGGCACCGAUCCCUGCUCCGUCGACGCCCGCAGAGGCCCGCCUUGGCCCGGGCUCUGGAGGCCAGUGCCU .........(..)........................(..).............................. >BC009853.1/63-1 GAGGCACCGAUCCCGGCUCCGUCGCCGCCCGCGAGGCCCGCCUUGGCCACGGGCCCUCGUGCC .........(..).......................(..)....................... >ABRP01221690.1/1794-1865 GAGGCACCGAUCCCUGCUCCGUCACCGCCCGCGCUGGCCCGCCUUGGCCACGGGCUCCGGAGGCCAGUGCCC .........(..)..............(..)......................................... >M97348.1/880-810 GAGGCGCCGAUCACUGCUCCGUCGCCGCCCGCAAGGCCCGCCUUGGCCGCGGGCUCUGGAGGCCAGCGCCC .........(..).......................(..)............................... >AF190058.1/714-646 GAGGCACCGAUCCCGGUCCGCCGCCGCCCGCGAGGCCCACCUUGGCCACGGCUCUGGAGGCCAGUGCCU .........(..)......................(..).............................. >AJ566210.1/5618-5549 AAGGCACCGAUCCCGCUCCGUCAUCGCCCGCAGAGGCCCGCCUUGGCCACGGGCUCGAAGUCCAGUGCCC .........(..).......................(..)..............................
3		C(CC)N A(UC)N G(CY(C))			17	89.5
>X07201.1/1693-1625 GAGUCACCGAUCACUGCUCCGUCGCCGCCCGCAAGCCUCCUUGGCCACGGACUCUGGAGGCCAGUGCCU .........(..)..(..(........(..).............................))....... >ABRN01220595.1/5512-5580 CGGACCGAUCCAUGCUCCGUCACCGCCCGCAGAGGCCCGCCUUGGCCAUGGGCUCGGAGGCCAGUGACC .......(..).............(..(.......(..)...................)..)....... >M97348.1/880-810 GAGGCGCCGAUCACUGCUCCGUCGCCGCCCGCAAGGCCCGCCUUGGCCGCGGGCUCUGGAGGCCAGCGCCC .........(..).............(..(......(..)...........................)).. >AY849926.1/1117-1048 GAGGCACCGAUCCCGCUCCGUCAUCGCCCGCAGAGGCCCGCCUUGGCCACGAGCUCGAAGUCCAAUGCCC .........(..)............(..(.......(..)...................)..)....... >AAYZ01478517.1/931-1000 AGGGCGCCGAUCUCGCUCCAUCGCAGCCCAUCAGGCCCACCUUGGCCACGGGCUCAGGAAGCCAGCGCCC .........(..).(..(.................(..).....................))........ >ACBE01354129.1/1652-1723 GAGGCACCGAUCCCUGCUCCGUCGUCGCCCGCAGAGGCCCACCUUGGCCACGGGCUCCGGAGGCCAGUGCCC .........(..)..(..(........(..)...............................))........ >AF190057.1/799-729 GAGGCACCGAUCCCUGCUCCGUCGACGCCCGCAGAGGCCCGCCUUGGCCCGGGCUCUGGAGGCCAGUGCCU .........(..).............(..(.......(..).......))..................... >BC025150.1/163-93 GAGACACCGAUCACUGCUCCGUCGCCGCCCGCAAGGCCCUCCUUGGCCACGGACUCUGGAGGCCAGUGCCU .........(..).............(..(......(..).....))........................ >AY091484.1/1481-1411 AAGGCACCGAUCCCGCUCCGUCAUCGCCCAGCAGAGGCCCGCCUUGGCCACGGGCUCGAAGUCCAGUGCCC .........(..)............(..(........(..)...................)..)....... >AAPY01607917.1/1901-1971 GAGGCACCGAUCACUGCUCCGUCGCUGCCCACGAGGCCCUCCUUGGCCAUGGGCUCUGGAGGCCAGUGCCC .........(..).............(..(......(..)...........................)).. >ABRP01221690.1/1794-1865 GAGGCACCGAUCCCUGCUCCGUCACCGCCCGCGCUGGCCCGCCUUGGCCACGGGCUCCGGAGGCCAGUGCCC .........(..)..(..(........(..)...............................))........ >BC053636.1/935-865 GAGGCACCGAUCCCGGCUCCGUCGCCGCCCGCGAGGCCCGCCUUGGCCACGGGCUCUGGAGGCCAGUGCCU .........(..)..(..(.................(..).....................))........ >AJ566210.1/5618-5549 AAGGCACCGAUCCCGCUCCGUCAUCGCCCGCAGAGGCCCGCCUUGGCCACGGGCUCGAAGUCCAGUGCCC .........(..)............(..(.......(..)...................)..)....... >AAWR02038016.1/7406-7476 GAGGCACCGAUCACUGCUCCAUCGCCGCCCGCACAGGCCCGCCUUGGCCGCGGGCUCCGGAGUCCAGGCCC .........(..).............(..(.......(..)..........................)).. >AF190058.1/714-646 GAGGCACCGAUCCCGGUCCGCCGCCGCCCGCGAGGCCCACCUUGGCCACGGCUCUGGAGGCCAGUGCCU .........(..)............(..(......(..)....................))........ >AF190056.1/755-685 GAGGCACCGAUCCCUGCUCCGUCGUCGCCCGCGGAGCCCACCUCGGCCACGGGCUCUGGAGGCCAGCGCCC .........(..)..(..(........(..)..............................))........ >BC009853.1/63-1 GAGGCACCGAUCCCGGCUCCGUCGCCGCCCGCGAGGCCCGCCUUGGCCACGGGCCCUCGUGCC .........(..)..(..(.................(..)............)).........
4		C(CC)N A(UC)N G(CY(C)) R(R(G))			11	57.9
>AY091484.1/1481-1411 AAGGCACCGAUCCCGCUCCGUCAUCGCCCAGCAGAGGCCCGCCUUGGCCACGGGCUCGAAGUCCAGUGCCC (.(......(..)............(..(........(..)...................)..).....)) >ACBE01354129.1/1652-1723 GAGGCACCGAUCCCUGCUCCGUCGUCGCCCGCAGAGGCCCACCUUGGCCACGGGCUCCGGAGGCCAGUGCCC (.(......(..)..(..(........(..)...............................))......)) >AY849926.1/1117-1048 GAGGCACCGAUCCCGCUCCGUCAUCGCCCGCAGAGGCCCGCCUUGGCCACGAGCUCGAAGUCCAAUGCCC (.(......(..)............(..(.......(..)...................)..).....)) >M97348.1/880-810 GAGGCGCCGAUCACUGCUCCGUCGCCGCCCGCAAGGCCCGCCUUGGCCGCGGGCUCUGGAGGCCAGCGCCC (.(......(..).............(..(......(..)...........................)))) >X07201.1/1693-1625 GAGUCACCGAUCACUGCUCCGUCGCCGCCCGCAAGCCUCCUUGGCCACGGACUCUGGAGGCCAGUGCCU (.(......(..)..(..(........(..).............................)).....)) >AAWR02038016.1/7406-7476 GAGGCACCGAUCACUGCUCCAUCGCCGCCCGCACAGGCCCGCCUUGGCCGCGGGCUCCGGAGUCCAGGCCC (.(......(..).............(..(.......(..)..........................)))) >AJ566210.1/5618-5549 AAGGCACCGAUCCCGCUCCGUCAUCGCCCGCAGAGGCCCGCCUUGGCCACGGGCUCGAAGUCCAGUGCCC (.(......(..)............(..(.......(..)...................)..).....)) >AAPY01607917.1/1901-1971 GAGGCACCGAUCACUGCUCCGUCGCUGCCCACGAGGCCCUCCUUGGCCAUGGGCUCUGGAGGCCAGUGCCC (.(......(..).............(..(......(..)...........................)))) >ABRP01221690.1/1794-1865 GAGGCACCGAUCCCUGCUCCGUCACCGCCCGCGCUGGCCCGCCUUGGCCACGGGCUCCGGAGGCCAGUGCCC (.(......(..)..(..(........(..)...............................))......)) >AF190058.1/714-646 GAGGCACCGAUCCCGGUCCGCCGCCGCCCGCGAGGCCCACCUUGGCCACGGCUCUGGAGGCCAGUGCCU (.(......(..)............(..(......(..)....................))......)) >AF190056.1/755-685 GAGGCACCGAUCCCUGCUCCGUCGUCGCCCGCGGAGCCCACCUCGGCCACGGGCUCUGGAGGCCAGCGCCC (.(......(..)..(..(........(..)..............................))......))
5		C(CC)N A(UC)N G(CY(C)) R(R(G)) ((C)U)C			9	47.4
>AJ566210.1/5618-5549 AAGGCACCGAUCCCGCUCCGUCAUCGCCCGCAGAGGCCCGCCUUGGCCACGGGCUCGAAGUCCAGUGCCC (.(......(..)............(..(.......(..)....((.......).)...)..).....)) >AY091484.1/1481-1411 AAGGCACCGAUCCCGCUCCGUCAUCGCCCAGCAGAGGCCCGCCUUGGCCACGGGCUCGAAGUCCAGUGCCC (.(......(..)............(..(........(..)....((.......).)...)..).....)) >AY849926.1/1117-1048 GAGGCACCGAUCCCGCUCCGUCAUCGCCCGCAGAGGCCCGCCUUGGCCACGAGCUCGAAGUCCAAUGCCC (.(......(..)............(..(.......(..)....((.......).)...)..).....)) >AAPY01607917.1/1901-1971 GAGGCACCGAUCACUGCUCCGUCGCUGCCCACGAGGCCCUCCUUGGCCAUGGGCUCUGGAGGCCAGUGCCC (.(......(..).............(..(......(..)....((.......).)...........)))) >X07201.1/1693-1625 GAGUCACCGAUCACUGCUCCGUCGCCGCCCGCAAGCCUCCUUGGCCACGGACUCUGGAGGCCAGUGCCU (.(......(..)..(..(........(..).........(.(........).)......)).....)) >M97348.1/880-810 GAGGCGCCGAUCACUGCUCCGUCGCCGCCCGCAAGGCCCGCCUUGGCCGCGGGCUCUGGAGGCCAGCGCCC (.(......(..).............(..(......(..)....((.......).)...........)))) >ABRP01221690.1/1794-1865 GAGGCACCGAUCCCUGCUCCGUCACCGCCCGCGCUGGCCCGCCUUGGCCACGGGCUCCGGAGGCCAGUGCCC (.(......(..)..(..(........(..).....(...(.............).).....))......)) >AF190058.1/714-646 GAGGCACCGAUCCCGGUCCGCCGCCGCCCGCGAGGCCCACCUUGGCCACGGCUCUGGAGGCCAGUGCCU (.(......(..)............(..(......(..)....((......).).....))......)) >AAWR02038016.1/7406-7476 GAGGCACCGAUCACUGCUCCAUCGCCGCCCGCACAGGCCCGCCUUGGCCGCGGGCUCCGGAGUCCAGGCCC (.(......(..).............(..(.......(..)....((.......).)..........))))

>AY849926.1/1117-1048 GAGGCACCGAUCCCGCUCCGUCAUCGCCCGCAGAGGCCCGCCUUGGCCACGAGCUCGAAGUCCAAUGCCC ....................................(..).............................. .........(..).......................(..).............................. .........(..)............(..(.......(..)...................)..)....... (.(......(..)............(..(.......(..)...................)..).....)) (.(......(..)............(..(.......(..)....((.......).)...)..).....)) >AJ566210.1/5618-5549 AAGGCACCGAUCCCGCUCCGUCAUCGCCCGCAGAGGCCCGCCUUGGCCACGGGCUCGAAGUCCAGUGCCC ...........(..)....................................................... .........(..).......................(..).............................. .........(..)............(..(.......(..)...................)..)....... (.(......(..)............(..(.......(..)...................)..).....)) (.(......(..)............(..(.......(..)....((.......).)...)..).....)) >AAWR02038016.1/7406-7476 GAGGCACCGAUCACUGCUCCAUCGCCGCCCGCACAGGCCCGCCUUGGCCGCGGGCUCCGGAGUCCAGGCCC .....................................(..).............................. .........(..)........................(..).............................. .........(..).............(..(.......(..)..........................)).. (.(......(..).............(..(.......(..)..........................)))) (.(......(..).............(..(.......(..)....((.......).)..........)))) >AAPY01607917.1/1901-1971 GAGGCACCGAUCACUGCUCCGUCGCUGCCCACGAGGCCCUCCUUGGCCAUGGGCUCUGGAGGCCAGUGCCC ....................................(..)............................... .........(..).......................(..)............................... .........(..).............(..(......(..)...........................)).. (.(......(..).............(..(......(..)...........................)))) (.(......(..).............(..(......(..)....((.......).)...........)))) >AY091484.1/1481-1411 AAGGCACCGAUCCCGCUCCGUCAUCGCCCAGCAGAGGCCCGCCUUGGCCACGGGCUCGAAGUCCAGUGCCC ...........(..)........................................................ .........(..)........................(..).............................. .........(..)............(..(........(..)...................)..)....... (.(......(..)............(..(........(..)...................)..).....)) (.(......(..)............(..(........(..)....((.......).)...)..).....)) >AF190058.1/714-646 GAGGCACCGAUCCCGGUCCGCCGCCGCCCGCGAGGCCCACCUUGGCCACGGCUCUGGAGGCCAGUGCCU ...........(..)...................................................... .........(..)......................(..).............................. .........(..)............(..(......(..)....................))........ (.(......(..)............(..(......(..)....................))......)) (.(......(..)............(..(......(..)....((......).).....))......)) >M97348.1/880-810 GAGGCGCCGAUCACUGCUCCGUCGCCGCCCGCAAGGCCCGCCUUGGCCGCGGGCUCUGGAGGCCAGCGCCC ....................................(..)............................... .........(..).......................(..)............................... .........(..).............(..(......(..)...........................)).. (.(......(..).............(..(......(..)...........................)))) (.(......(..).............(..(......(..)....((.......).)...........)))) >X07201.1/1693-1625 GAGUCACCGAUCACUGCUCCGUCGCCGCCCGCAAGCCUCCUUGGCCACGGACUCUGGAGGCCAGUGCCU ...........................(..)...................................... .........(..)..............(..)...................................... .........(..)..(..(........(..).............................))....... (.(......(..)..(..(........(..).............................)).....)) (.(......(..)..(..(........(..).........(.(........).)......)).....)) >ABRP01221690.1/1794-1865 GAGGCACCGAUCCCUGCUCCGUCACCGCCCGCGCUGGCCCGCCUUGGCCACGGGCUCCGGAGGCCAGUGCCC ...........................(..)......................................... .........(..)..............(..)......................................... .........(..)..(..(........(..)...............................))........ (.(......(..)..(..(........(..)...............................))......)) (.(......(..)..(..(........(..).....(...(.............).).....))......)) >AF190056.1/755-685 GAGGCACCGAUCCCUGCUCCGUCGUCGCCCGCGGAGCCCACCUCGGCCACGGGCUCUGGAGGCCAGCGCCC ...........................(..)........................................ .........(..)..............(..)........................................ .........(..)..(..(........(..)..............................))........ (.(......(..)..(..(........(..)..............................))......)) >ACBE01354129.1/1652-1723 GAGGCACCGAUCCCUGCUCCGUCGUCGCCCGCAGAGGCCCACCUUGGCCACGGGCUCCGGAGGCCAGUGCCC ...........................(..)......................................... .........(..)..............(..)......................................... .........(..)..(..(........(..)...............................))........ (.(......(..)..(..(........(..)...............................))......)) >AF190057.1/799-729 GAGGCACCGAUCCCUGCUCCGUCGACGCCCGCAGAGGCCCGCCUUGGCCCGGGCUCUGGAGGCCAGUGCCU .....................................(..).............................. .........(..)........................(..).............................. .........(..).............(..(.......(..).......))..................... >BC053636.1/935-865 GAGGCACCGAUCCCGGCUCCGUCGCCGCCCGCGAGGCCCGCCUUGGCCACGGGCUCUGGAGGCCAGUGCCU ....................................(..)............................... .........(..).......................(..)............................... .........(..)..(..(.................(..).....................))........ >AAYZ01478517.1/931-1000 AGGGCGCCGAUCUCGCUCCAUCGCAGCCCAUCAGGCCCACCUUGGCCACGGGCUCAGGAAGCCAGCGCCC ...................................(..)............................... .........(..)......................(..)............................... .........(..).(..(.................(..).....................))........ >BC009853.1/63-1 GAGGCACCGAUCCCGGCUCCGUCGCCGCCCGCGAGGCCCGCCUUGGCCACGGGCCCUCGUGCC ....................................(..)....................... .........(..).......................(..)....................... .........(..)..(..(.................(..)............))......... >ABRN01220595.1/5512-5580 CGGACCGAUCCAUGCUCCGUCACCGCCCGCAGAGGCCCGCCUUGGCCAUGGGCUCGGAGGCCAGUGACC ...................................(..).............................. .......(..)........................(..).............................. .......(..).............(..(.......(..)...................)..)....... >BC025150.1/163-93 GAGACACCGAUCACUGCUCCGUCGCCGCCCGCAAGGCCCUCCUUGGCCACGGACUCUGGAGGCCAGUGCCU ....................................(..)............................... .........(..).......................(..)............................... .........(..).............(..(......(..).....))........................ >AAKN02038607.1/34760-34690 GAGGCACCGAUCACUGCUCCGUCGUCACCUGCGAGGCCCACCUUGGCCACAGGCUCUGGAGGCCAGUGCCU ....................................(..)............................... .........(..).......................(..)............................... >AF214115.1/1092-1022 GAGGCACCGAUCACUGCUCCGUCGCCGCCCGCAAGGCCCUCCUUGGCCACGGACUCUGGAGGCCAGUGCCU ....................................(..)............................... .........(..).......................(..)...............................

	ORB			p-value	ORB frequency (per structure per nucleotide)	Means ratio
1	C(CC)N			< 0.001		35.9

AF190058.1/714-646 GAGGCACCGAUCCCGGUCCGCCGCCGCCCGCGAGGCCCACCUUGGCCACGGCUCUGGAGGCCAGUGCCU GAGGCACCGAUCCCGGUCCGCCGCCGCCCGCGAGGCCCACCUUGGCCACGGCUCUGGAGGCCAGUGCCU GAGGCACCGAUCCCGGUCCGCCGCCGCCCGCGAGGCCCACCUUGGCCACGGCUCUGGAGGCCAGUGCCU .........1.........2.........3.........4.........5.........6......... 123456789012345678901234567890123456789012345678901234567890123456789
2	A(UC)N			< 0.001		3.83

AF190058.1/714-646 GAGGCACCGAUCCCGGUCCGCCGCCGCCCGCGAGGCCCACCUUGGCCACGGCUCUGGAGGCCAGUGCCU .........1.........2.........3.........4.........5.........6......... 123456789012345678901234567890123456789012345678901234567890123456789
3	G(CY(C))			< 0.001		6.92

AF190058.1/714-646 GAGGCACCGAUCCCGGUCCGCCGCCGCCCGCGAGGCCCACCUUGGCCACGGCUCUGGAGGCCAGUGCCU GAGGCACCGAUCCCGGUCCGCCGCCGCCCGCGAGGCCCACCUUGGCCACGGCUCUGGAGGCCAGUGCCU GAGGCACCGAUCCCGGUCCGCCGCCGCCCGCGAGGCCCACCUUGGCCACGGCUCUGGAGGCCAGUGCCU GAGGCACCGAUCCCGGUCCGCCGCCGCCCGCGAGGCCCACCUUGGCCACGGCUCUGGAGGCCAGUGCCU GAGGCACCGAUCCCGGUCCGCCGCCGCCCGCGAGGCCCACCUUGGCCACGGCUCUGGAGGCCAGUGCCU GAGGCACCGAUCCCGGUCCGCCGCCGCCCGCGAGGCCCACCUUGGCCACGGCUCUGGAGGCCAGUGCCU .........1.........2.........3.........4.........5.........6......... 123456789012345678901234567890123456789012345678901234567890123456789
4	((C)U)C			< 0.001		7.67

AF190058.1/714-646 GAGGCACCGAUCCCGGUCCGCCGCCGCCCGCGAGGCCCACCUUGGCCACGGCUCUGGAGGCCAGUGCCU GAGGCACCGAUCCCGGUCCGCCGCCGCCCGCGAGGCCCACCUUGGCCACGGCUCUGGAGGCCAGUGCCU GAGGCACCGAUCCCGGUCCGCCGCCGCCCGCGAGGCCCACCUUGGCCACGGCUCUGGAGGCCAGUGCCU GAGGCACCGAUCCCGGUCCGCCGCCGCCCGCGAGGCCCACCUUGGCCACGGCUCUGGAGGCCAGUGCCU GAGGCACCGAUCCCGGUCCGCCGCCGCCCGCGAGGCCCACCUUGGCCACGGCUCUGGAGGCCAGUGCCU GAGGCACCGAUCCCGGUCCGCCGCCGCCCGCGAGGCCCACCUUGGCCACGGCUCUGGAGGCCAGUGCCU .........1.........2.........3.........4.........5.........6......... 123456789012345678901234567890123456789012345678901234567890123456789
5	R(R(G))			< 0.001		5.14

AF190058.1/714-646 GAGGCACCGAUCCCGGUCCGCCGCCGCCCGCGAGGCCCACCUUGGCCACGGCUCUGGAGGCCAGUGCCU GAGGCACCGAUCCCGGUCCGCCGCCGCCCGCGAGGCCCACCUUGGCCACGGCUCUGGAGGCCAGUGCCU GAGGCACCGAUCCCGGUCCGCCGCCGCCCGCGAGGCCCACCUUGGCCACGGCUCUGGAGGCCAGUGCCU GAGGCACCGAUCCCGGUCCGCCGCCGCCCGCGAGGCCCACCUUGGCCACGGCUCUGGAGGCCAGUGCCU .........1.........2.........3.........4.........5.........6......... 123456789012345678901234567890123456789012345678901234567890123456789
	ORB			p-value	ORB frequency (per structure per nucleotide)	Means ratio

	NCM			p-value	NCM frequency (per structure per nucleotide)	Means ratio
1	.YGCYC.			< 0.001		34.6

AF190058.1/714-646 GAGGCACCGAUCCCGGUCCGCCGCCGCCCGCGAGGCCCACCUUGGCCACGGCUCUGGAGGCCAGUGCCU .........1.........2.........3.........4.........5.........6......... 123456789012345678901234567890123456789012345678901234567890123456789
2	.CCRRU.			< 0.001		4

AF190058.1/714-646 GAGGCACCGAUCCCGGUCCGCCGCCGCCCGCGAGGCCCACCUUGGCCACGGCUCUGGAGGCCAGUGCCU .........1.........2.........3.........4.........5.........6......... 123456789012345678901234567890123456789012345678901234567890123456789
	NCM			p-value	NCM frequency (per structure per nucleotide)	Means ratio

Structure is visualized using R2R 1.0.6 (Zasha Weinberg).
LOGOS are generated with ggseqlogo (Omar Wagih).