D-ORB

The Overrepresented RNA Blocks

M.J. Dupont, F. Major

D-ORB: A Web Server to Extract Structural Features of Related But Unaligned RNA Sequences

J. Mol. Biol., 435 (2023)

S-adenosyl-L-homocysteine riboswitch (Rfam: RF01057)

Options

Negatives sequences: Random sequences of similar lengths
ORBs positions sequence: Best consensus structure-matching sequence
Motifs: 162,498 motifs on the alphabet ACGURYN

Rfam

D-ORB

Augmented

G(C(R)())
(C()N)
((C)R)Y

90.4
98.1
98.1

% of positive sequence with ORB

Job*

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Sequence(s)*

Obtain

One structure matching the consensus structure ORBs
Several structures containing instances of most discriminative ORBs

Up to structures per sequence

Position offset nucleotides

Job*

Email*

Wildtype sequence*

Mutant sequences

All SNPs
Submit mutant sequences

Use the mutation generator

Deep neural network:

5-fold cross-validation: 98.4 %
(± 0.2 %)

Decision tree:

5-fold cross-validation: 80.6 %
(± 2.08 %)

D-ORB structure

D-ORB structure decision tree:

5-fold cross-validation: 82.9 %
(± 6.58 %)

of CP000539.1/650534-650615

CP000539.1/650534-650615

CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG
(..((.(.(((((((((.(((((((((((..))).))))))))(((((((((((..))))))))))))))))))).)).)))
.........1.........2.........3.........4.........5.........6.........7.........8..
1234567890123456789012345678901234567890123456789012345678901234567890123456789012

abstract shape: `(()())`

					Number of sequences
	Structure	ORBs			(out of 52)	(%)
1		G(C(R)())			43	82.7
>CP000539.1/650534-650615 CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG ................(.(.......................)(......................)).............. >AM406670.1/4083393-4083321 CCUGCCGAGGAGCGCUGCGACCCGAAAUCACGCCGGGCCAGGCUCGGCAACCGAACAACGGCGCUCGCAAACC ................(.(..................)(..................)).............. >CP000090.1/239471-239552 CACUCCGAGGAGCGUUGCAACGGAUCGUGGCGUAACAUGCCCUCCGCCAGGCUCGGACUGUCUUCAACGGCGCUCGCUGAUC ................(.(.....................................)(........)).............. >CP000542.1/736268-736181 CGCUCCGAGGAGCGUUGCAGCGCCUCCCACCGGCAGGGCCGGCGGGGCGUGAGGCUCGGGCAUCAUCUGGCAACGACGCUCAUCCACA ...................(.(.........................)(................))..................... >AASZ01001430.1/3908-3830 CACCGAGGAGCGUUGCAACGGGACAAGGUCCCGCCAGGCUCGGUGAGGGCUCCAUAAGUUUCAACGGCGCUUACUCUGA ..............(.(..................)(......................)....).............. >CP000453.1/2565212-2565295 CGCCCCGAGGAGCGCUGCAACAGGGCCGCCGGCCCUGCCAGGCUCGGGGAUGGCGCCCCAUCGUUCCAACGGCGCUCAGCGAAA ................(.(....................)(.........................)..).............. >DQ996270.1/1772-1706 UUUCCGAGGAGCGUUGCGACGGGCACCGGCCCGCCAGGCUCGGAAAUCUUCACCAGGCGGUGGCCCG ..........(.(.................................)(..............))... >CP000555.1/3494432-3494509 ACUUUCGAGGAGCGUUGCAACUCCCGCCCGGGAGCCAGGCUCGAAAGUCAUCCCCCGAUGCAACGGCGCUCACCCGCA ................(.(.................)(.......................).).............. >CP000949.1/538083-537987 CUGUCCGAGGGGCGCUGCAGCAGGGUCAUCCUGUCAGGCUCGGAUGGGGCGUUGUCCGCUCCCGCGGACGCUCAACGCACAACGGCGCCCAUUCGCA ................(.(.........................).(................................)..).............. >CP000529.1/516171-516245 UCUCCUGAGGAGCGUUGCAACCCACGGCAUGUGGUCUAGGCUCAGGACUUCUAUUUGCAACCACGCUCACCCGCA ................(.(................................)(......)).............. >CP000304.1/4264519-4264605 CCACCCGAGGGGCGCUGCAGCAGGUUCCAGAACCUGUCAGGCUCGGAUGGGGCGUUUCCUCGAACGCAUCAACGGCGCCCAUUCGCA ................(.(..................)(...............................).).............. >CP000113.1/8035799-8035872 GACUUCGAGGAGCGCUGCGAGGCCGGACCCGGCCCCAGGCUCGAAGCGGAAUCACCCAACGGCGCUCACCUGUA ...........(.(........................)(.......................))......... >AL646052.1/107656-107582 AUUCCGAGGAGCGUUGCAACGGACCGGCAUCCGCCCGGCCGCCAGGCUCGGAAGUUCAAACGGCGCUCGCACUAU ...............(.(........................)(..............).).............. >CP000450.1/2008790-2008713 UUGUACCGAGGAGCGCUGCAACGGUCUAUCUCGUGAGGCUCGGACAAAUGAACAACCCAACAACGGCGCUCUUUCACU .................(.(..............)(......................)....).............. >AE017282.2/144280-144199 GCGCCGAGGAGCGCUGCGACGGCCCGUCGAGGGCCGCCAGGCUCGGCGGGGACAAUCGGUUUUCCAACGGCGCUCUGUUUAU ...............(.(...................).(........................)..).............. >CP002271.1/7720690-7720757 CAACCUGAGGAGCGCUGCAACGGGGACUUCCCGCCAGGCUCAGGUUCAUGUAACGGCGCUCGCUGACU ................(.(........................)(.......)).............. >CP000089.1/57505-57435 UCUGCCGAGGAGCGCUGCGACCCUUUAAUUCGGGGGCCAGGCUCGGCAAUGAUCAACGGCGCUCGCAAACC ................(.(.................)(.................)).............. >CP000352.1/177418-177491 CACUCCGAGGAGCGUUGCAACGGAUGGCCUCGCCUUCCGCCAGGCUCGGAAUGUUUCAACGGCGCUCGCAGUUC ................(.(.....................)(.............))................. >AATN01000007.1/46422-46509 GCCUGAGGAGCGCUGCAACGGUUAGCAGAUAUUAACUCGCUAACCGCUAGGCUCAGGCAAUCAUUUAGAUUAACUGCGCUCAUUCAAU ..............(.(.............................)(.......................).).............. >AAUJ02000001.1/4967434-4967338 CCAUCCGAGGAGCGUUGCAGCGUUCCCCAGCCAGCCAUGAGCUGGCCUGCGCGGGGCGUGAGGCUCGGAUUUCAUCCCGCAACGACGCUCGCCCACG ................(.(.................................)(...........................)).............. >AACY020581805.1/324-399 UCUUCCGAGGAGCGUUGCAACCGCCACUUUAGCUUGGCGGCCAGGCUCGGAACCGUGACAACGGCGCUCACCCGCA ................(.(.....................)(..................)).............. >CP000680.1/478968-478877 CCGUCCGAGGGGCGCUGCAGCAGGUCGGUCGACACCGGUUUGUCAGGCUCGGAUGGGGCGUUAACCAUACGCAUCAACGGCGCCCAUUCGCA ................(.(........................).(............................)..).............. >AASZ01000145.1/12763-12838 CCUGUGUGCGAGGAGCGCUGCGACAGCUUAACUGCCAGGCUCGCCCACUGGAUCAAUGCAACGGCGCUCGUAAAUA ...................(.(......................).(.............)).............. >AAFX01122445.1/162-87 GCUUCGAGGAGCGCUGCGACUUGCGUGGUUUGCAAGCCAGGCUCGGAGCAUUCGACAGGAACGGCGCUCACCCACU ...............(.(............................)(............)).............. >CP001715.1/470000-469928 CAAUCCGAGGAGCGCUGCAGGGCCGUCGAUCGACGGUUUCAGGCUCGGAUUCCUUAAACGGCGCUCAUCCGAC ................(.(..................)(..................)).............. >CP000086.1/3610417-3610350 GUUUCCGAGGAGCGUUGCGACGGGCCCCGCCCGCCAGGCUCGGAAAUGGUCAACCGAGCGGUGUGUCU ................(.(........................)(............))......... >CP000116.1/2591667-2591597 GGUUCCGAGGAGCGCUGCGACGGUUCACCCGCCAGGCUCGGGACGCUUCCUUUCAACGGCGCUCACGUUUU ................(.(.................)(.................)).............. >AM260479.1/256130-256245 CACUCCGAGGAGCGUUGCAACGGAUGGAGGCCUGCGAAGCACAUCGCGCGGCCGGCGGCACAGCCGCCCCAUGCCAUCCGCCAGGCUCGGACUGUCUUCAACGGCGCUCGCUGAUC .................................(.(........)(..................................)).................................. >CP001111.1/740018-739937 CUGCCGAGGGGCGCUGCGACCGGAUCCCUUGAGGCCGGCCAGGCUCGGCCAGGUGGUACUGCAACAACGGCGCCCGGCCAGA ...............(.(.....................)(......................))................. >CP000267.1/475493-475563 UCUUCCAAGGAGCGUUGCAGUCGGCCACAUGGCCGGUCAGGCUUGGAUGACCCCAACGACGCUCACCUGAU ................(.(..................)(...............).).............. >CP000103.1/2909965-2909888 CAGACCGAGGAGCGCUGCAACGGGCAUUGUCCCGCGAGGCUCGGCAAGGAAGGAUCGCUACAACGGCGCUCGUUCAUU ................(.(........................).(................)).............. >CP000094.2/5940642-5940740 CUGUCCGAGGGGCGCUGCAGCAGGUUCAACCUGUCAGGCUCGGAUGGGGCGUUGACCGGCUCAGGCCGGACACUAAACGCACAACGGCGCCCAUUCGCA ................(.(.........................)(....................................).).............. >ABCT01000021.1/8794-8876 CCGUUCGAGGAGCGUUGCGACACACCCAUGCUUUUUUGGGGUGCUAGGCUCGAACAAGAAAUAAACAACGGCGCUCACGCUUC ................(.(........................)(......................)).............. >CP000884.1/6586554-6586470 CUCUCCGAGGAGCGUUGCAGCGGCCCCCACACAUCAGGCGUGGUCGCGAGGCUCGGAGUCAUACCUGCAACGACGCUCGCCCACG ...................(.(......................)(..........................))........... >AATN01006348.1/58-129 AAUCCGAGGAGCGCUGCAAGGCUGUCGUCCCACAGUUUCAGGCUCGGAUUCAUCAAACGGCGCUCAUCCCAC ...............(.(...................)(.................)).............. >CP001157.1/337304-337216 CCUUCCGAGGGGCGCUGCAGCAGGCCUGCCAACGGCCUGUCAGGCUCGGAAGGGGCGUUUUCCGAACGCAUCAACGGCGCCCAUUCGCA ................(.(..........................)...(......................).).............. >CR555306.1/1088385-1088448 UGCCGAGGAGCGCUGCGAGACUUCCGUCCCAGGCUCGGCCCUUCAAAAACUGCGCUCACCUUAA .........(.(.....................).(.................))......... >AAFX01048275.1/188-258 CAUUAGCUGAGGAGCGCUGCAACUCCGGUUUACGGAACCAGGCUCAGCAAAUGAAACGGCGCUCGUUCCAA ..................(.(.................)(...............)).............. >AE015451.1/5667868-5667964 CUGUCCGAGGGGCGCUGCAGCAGGCUAGGCCUGUCAGGCUCGGAUGGGGCGUUGCUCGCUCCCGCGAGCGCUUAACGCACAACGGCGCCCAUUCGCA ................(.(.........................).(................................)..).............. >CP000744.1/550599-550494 CCGUUCGAGGGGCGCUGCAGCAGGCCUAGGCCUGUCAGGCUCGAACGGAGCGCGCUCUCAGGCCGGCCUCGCCGGUCUGUCAACGCACCAACGGCGCCCAUUCGCA ................(.(.........................)...(.......................................)..).............. >AATO01002448.1/1018-1089 AAUCCGAGGGGCGCUGCAGGGCUGUCGUUCGACAGUUUCAGGCUCGGAUUUCUCAAACGGCGCUCAUCCAAC ...............(.(....................)(................)).............. >AATN01000007.1/45143-45222 ACUGAGGAGCGUUGCGACAGGUUUUCCUGCCAGGCUCAGUAGAUUGAAGGACAAUUUAAAUACAACGGCGCUCAGUCAUC .............(.(....................)(.........................).).............. >CT573326.1/5348242-5348337 CCGGCCGAGGGGCGCUGCAGCAGGUUCGUCCUGUCAGGCUCGGUCGGGGCGUUGUCCGCGCAGCGGACGCUCAACGCACAACGGCGCCCAUUCGCA ...................(.(........................).(...........................).).................
2		G(C(R)()) (C()N)			32	61.5
>AM406670.1/4083393-4083321 CCUGCCGAGGAGCGCUGCGACCCGAAAUCACGCCGGGCCAGGCUCGGCAACCGAACAACGGCGCUCGCAAACC ...(.(..........(.(...................)(.................))..........).). >CP000089.1/57505-57435 UCUGCCGAGGAGCGCUGCGACCCUUUAAUUCGGGGGCCAGGCUCGGCAAUGAUCAACGGCGCUCGCAAACC ...(.(..........(.(.................)(.................))...........).) >CP000116.1/2591667-2591597 GGUUCCGAGGAGCGCUGCGACGGUUCACCCGCCAGGCUCGGGACGCUUCCUUUCAACGGCGCUCACGUUUU ...(.(..........(.(.............)(.....................)).........).).. >CP000949.1/538083-537987 CUGUCCGAGGGGCGCUGCAGCAGGGUCAUCCUGUCAGGCUCGGAUGGGGCGUUGUCCGCUCCCGCGGACGCUCAACGCACAACGGCGCCCAUUCGCA ...(.(..........(.(.........................).(................................)..)...........).) >CP001715.1/470000-469928 CAAUCCGAGGAGCGCUGCAGGGCCGUCGAUCGACGGUUUCAGGCUCGGAUUCCUUAAACGGCGCUCAUCCGAC ....(.(.........(.(....................)(............)....).........).).. >CP000113.1/8035799-8035872 GACUUCGAGGAGCGCUGCGAGGCCGGACCCGGCCCCAGGCUCGAAGCGGAAUCACCCAACGGCGCUCACCUGUA ....(.(.........(.(................)(....................).).........).).. >AASZ01001430.1/3908-3830 CACCGAGGAGCGUUGCAACGGGACAAGGUCCCGCCAGGCUCGGUGAGGGCUCCAUAAGUUUCAACGGCGCUUACUCUGA ..(.(.........(.(..................)(......................)....)..........).). >AATO01002448.1/1018-1089 AAUCCGAGGGGCGCUGCAGGGCUGUCGUUCGACAGUUUCAGGCUCGGAUUUCUCAAACGGCGCUCAUCCAAC ..(.(..........(.(....................)(................))..........).). >CP000453.1/2565212-2565295 CGCCCCGAGGAGCGCUGCAACAGGGCCGCCGGCCCUGCCAGGCUCGGGGAUGGCGCCCCAUCGUUCCAACGGCGCUCAGCGAAA ...(.(..........(.(....................)(.........................)..)..........).). >CP000103.1/2909965-2909888 CAGACCGAGGAGCGCUGCAACGGGCAUUGUCCCGCGAGGCUCGGCAAGGAAGGAUCGCUACAACGGCGCUCGUUCAUU ...(.(..........(.(.........................)(................))..........).). >AATN01006348.1/58-129 AAUCCGAGGAGCGCUGCAAGGCUGUCGUCCCACAGUUUCAGGCUCGGAUUCAUCAAACGGCGCUCAUCCCAC ..(.(..........(.(....................)....(............))..........).). >CT573326.1/5348242-5348337 CCGGCCGAGGGGCGCUGCAGCAGGUUCGUCCUGUCAGGCUCGGUCGGGGCGUUGUCCGCGCAGCGGACGCUCAACGCACAACGGCGCCCAUUCGCA ....(.(............(.(........................).(...........................).)............).).. >CP000529.1/516171-516245 UCUCCUGAGGAGCGUUGCAACCCACGGCAUGUGGUCUAGGCUCAGGACUUCUAUUUGCAACCACGCUCACCCGCA ..(.(...........(.(................................)(......))...........).) >CP001111.1/740018-739937 CUGCCGAGGGGCGCUGCGACCGGAUCCCUUGAGGCCGGCCAGGCUCGGCCAGGUGGUACUGCAACAACGGCGCCCGGCCAGA ...(.(.........(.(.........)(..................................)).........).)..... >AACY020581805.1/324-399 UCUUCCGAGGAGCGUUGCAACCGCCACUUUAGCUUGGCGGCCAGGCUCGGAACCGUGACAACGGCGCUCACCCGCA ...(.(..........(.(.....................)(..................))...........).) >CP000086.1/3610417-3610350 GUUUCCGAGGAGCGUUGCGACGGGCCCCGCCCGCCAGGCUCGGAAAUGGUCAACCGAGCGGUGUGUCU ...(.(..........(.(...............).(.............))..........).)... >AAFX01122445.1/162-87 GCUUCGAGGAGCGCUGCGACUUGCGUGGUUUGCAAGCCAGGCUCGGAGCAUUCGACAGGAACGGCGCUCACCCACU ..........(.(.........(.(................)(...........))........).)......... >CP000094.2/5940642-5940740 CUGUCCGAGGGGCGCUGCAGCAGGUUCAACCUGUCAGGCUCGGAUGGGGCGUUGACCGGCUCAGGCCGGACACUAAACGCACAACGGCGCCCAUUCGCA ...(.(..........(.(.........................)(....................................).)...........).) >AL646052.1/107656-107582 AUUCCGAGGAGCGUUGCAACGGACCGGCAUCCGCCCGGCCGCCAGGCUCGGAAGUUCAAACGGCGCUCGCACUAU ..(.(..........(.(........................)(..............).).........).).. >CP002271.1/7720690-7720757 CAACCUGAGGAGCGCUGCAACGGGGACUUCCCGCCAGGCUCAGGUUCAUGUAACGGCGCUCGCUGACU ..(.(...........(.(........................)(.......))..........).). >AAUJ02000001.1/4967434-4967338 CCAUCCGAGGAGCGUUGCAGCGUUCCCCAGCCAGCCAUGAGCUGGCCUGCGCGGGGCGUGAGGCUCGGAUUUCAUCCCGCAACGACGCUCGCCCACG ...(.(..........(.(.................................)(...........................)).......).).... >CP000267.1/475493-475563 UCUUCCAAGGAGCGUUGCAGUCGGCCACAUGGCCGGUCAGGCUUGGAUGACCCCAACGACGCUCACCUGAU ...(.(..........(.(.........)(........................).)..........).). >AATN01000007.1/46422-46509 GCCUGAGGAGCGCUGCAACGGUUAGCAGAUAUUAACUCGCUAACCGCUAGGCUCAGGCAAUCAUUUAGAUUAACUGCGCUCAUUCAAU .(.(..........(.(.............................)(.......................).)...........).) >CP001157.1/337304-337216 CCUUCCGAGGGGCGCUGCAGCAGGCCUGCCAACGGCCUGUCAGGCUCGGAAGGGGCGUUUUCCGAACGCAUCAACGGCGCCCAUUCGCA ...(.(..........(.(..........................)...(......................).)...........).) >CP000304.1/4264519-4264605 CCACCCGAGGGGCGCUGCAGCAGGUUCCAGAACCUGUCAGGCUCGGAUGGGGCGUUUCCUCGAACGCAUCAACGGCGCCCAUUCGCA ...(.(..........(.(..................)(...............................).)...........).) >AE017282.2/144280-144199 GCGCCGAGGAGCGCUGCGACGGCCCGUCGAGGGCCGCCAGGCUCGGCGGGGACAAUCGGUUUUCCAACGGCGCUCUGUUUAU ..(.(..........(.(...................).(........................)..)..........).). >CP000680.1/478968-478877 CCGUCCGAGGGGCGCUGCAGCAGGUCGGUCGACACCGGUUUGUCAGGCUCGGAUGGGGCGUUAACCAUACGCAUCAACGGCGCCCAUUCGCA ...(.(..........(.(........................).(............................)..)...........).) >CP000555.1/3494432-3494509 ACUUUCGAGGAGCGUUGCAACUCCCGCCCGGGAGCCAGGCUCGAAAGUCAUCCCCCGAUGCAACGGCGCUCACCCGCA ....(.(.........(.(................)(.........................)).........).).. >AE015451.1/5667868-5667964 CUGUCCGAGGGGCGCUGCAGCAGGCUAGGCCUGUCAGGCUCGGAUGGGGCGUUGCUCGCUCCCGCGAGCGCUUAACGCACAACGGCGCCCAUUCGCA ...(.(..........(.(........................)(....................................))...........).) >AATN01000007.1/45143-45222 ACUGAGGAGCGUUGCGACAGGUUUUCCUGCCAGGCUCAGUAGAUUGAAGGACAAUUUAAAUACAACGGCGCUCAGUCAUC (.(..........(.(....................)(.........................).)..........).). >CP000539.1/650534-650615 CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG ...(.(..........(.(.......................)(......................))..........).). >CP000352.1/177418-177491 CACUCCGAGGAGCGUUGCAACGGAUGGCCUCGCCUUCCGCCAGGCUCGGAAUGUUUCAACGGCGCUCGCAGUUC ...(.(..........(.(.....................)(.............))..........).)....
3		G(C(R)()) (C()N) ((C)R)Y			20	38.5
>CP002271.1/7720690-7720757 CAACCUGAGGAGCGCUGCAACGGGGACUUCCCGCCAGGCUCAGGUUCAUGUAACGGCGCUCGCUGACU ..(.(...((......(.(........................)(.......))......).).).). >CP000680.1/478968-478877 CCGUCCGAGGGGCGCUGCAGCAGGUCGGUCGACACCGGUUUGUCAGGCUCGGAUGGGGCGUUAACCAUACGCAUCAACGGCGCCCAUUCGCA ...(.(..((......(.(........................).(............................)..)......).)..).) >AATN01000007.1/46422-46509 GCCUGAGGAGCGCUGCAACGGUUAGCAGAUAUUAACUCGCUAACCGCUAGGCUCAGGCAAUCAUUUAGAUUAACUGCGCUCAUUCAAU .(.(..((......(.(.............................)(.......................).)......).)..).) >CP000555.1/3494432-3494509 ACUUUCGAGGAGCGUUGCAACUCCCGCCCGGGAGCCAGGCUCGAAAGUCAUCCCCCGAUGCAACGGCGCUCACCCGCA ....(.(.((......(.(................)(.........................))......).)).).. >CP000089.1/57505-57435 UCUGCCGAGGAGCGCUGCGACCCUUUAAUUCGGGGGCCAGGCUCGGCAAUGAUCAACGGCGCUCGCAAACC ...(.(..((......(.(.................)(.................))......).)..).) >AATO01002448.1/1018-1089 AAUCCGAGGGGCGCUGCAGGGCUGUCGUUCGACAGUUUCAGGCUCGGAUUUCUCAAACGGCGCUCAUCCAAC ..(.(.(.(......(.(....................)(................))......).).).). >CP000113.1/8035799-8035872 GACUUCGAGGAGCGCUGCGAGGCCGGACCCGGCCCCAGGCUCGAAGCGGAAUCACCCAACGGCGCUCACCUGUA ....(.(.((......(.(................)(....................).)......).)).).. >CT573326.1/5348242-5348337 CCGGCCGAGGGGCGCUGCAGCAGGUUCGUCCUGUCAGGCUCGGUCGGGGCGUUGUCCGCGCAGCGGACGCUCAACGCACAACGGCGCCCAUUCGCA ....(.(.((......(.(....................)(.......................................))......).)).).. >CP000094.2/5940642-5940740 CUGUCCGAGGGGCGCUGCAGCAGGUUCAACCUGUCAGGCUCGGAUGGGGCGUUGACCGGCUCAGGCCGGACACUAAACGCACAACGGCGCCCAUUCGCA ...(.(..((......(.(.........................)(....................................).)......).)..).) >AATN01006348.1/58-129 AAUCCGAGGAGCGCUGCAAGGCUGUCGUCCCACAGUUUCAGGCUCGGAUUCAUCAAACGGCGCUCAUCCCAC ..(.(.(.(......(.(....................)....(............))......).).).). >AM406670.1/4083393-4083321 CCUGCCGAGGAGCGCUGCGACCCGAAAUCACGCCGGGCCAGGCUCGGCAACCGAACAACGGCGCUCGCAAACC ...(.(..((......(.(...................)(.................))......).).).). >AL646052.1/107656-107582 AUUCCGAGGAGCGUUGCAACGGACCGGCAUCCGCCCGGCCGCCAGGCUCGGAAGUUCAAACGGCGCUCGCACUAU ..(.(..((......(.(........................)(..............).)......).)).).. >CP000352.1/177418-177491 CACUCCGAGGAGCGUUGCAACGGAUGGCCUCGCCUUCCGCCAGGCUCGGAAUGUUUCAACGGCGCUCGCAGUUC ...(.(..((......(.(.....................)(.............)).....).)..).).... >CP000116.1/2591667-2591597 GGUUCCGAGGAGCGCUGCGACGGUUCACCCGCCAGGCUCGGGACGCUUCCUUUCAACGGCGCUCACGUUUU ...(.(..((......(.(.............)(.....................))......).)).).. >CP000304.1/4264519-4264605 CCACCCGAGGGGCGCUGCAGCAGGUUCCAGAACCUGUCAGGCUCGGAUGGGGCGUUUCCUCGAACGCAUCAACGGCGCCCAUUCGCA ...(.(..((......(.(..................)(...............................).)......).)..).) >CP000949.1/538083-537987 CUGUCCGAGGGGCGCUGCAGCAGGGUCAUCCUGUCAGGCUCGGAUGGGGCGUUGUCCGCUCCCGCGGACGCUCAACGCACAACGGCGCCCAUUCGCA ...(.(..((......(.(.........................).(................................)..)......).)..).) >CP001157.1/337304-337216 CCUUCCGAGGGGCGCUGCAGCAGGCCUGCCAACGGCCUGUCAGGCUCGGAAGGGGCGUUUUCCGAACGCAUCAACGGCGCCCAUUCGCA ...(.(..((......(.(..........................)...(......................).)......).)..).) >AE015451.1/5667868-5667964 CUGUCCGAGGGGCGCUGCAGCAGGCUAGGCCUGUCAGGCUCGGAUGGGGCGUUGCUCGCUCCCGCGAGCGCUUAACGCACAACGGCGCCCAUUCGCA ...(.(..((......(.(........................)(....................................))......).)..).) >CP000539.1/650534-650615 CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG ...(.(..((......(.(.......................)(......................))......).).).). >AACY020581805.1/324-399 UCUUCCGAGGAGCGUUGCAACCGCCACUUUAGCUUGGCGGCCAGGCUCGGAACCGUGACAACGGCGCUCACCCGCA ...(.(..((......(.(.....................)(..................))......).)..).)

>CP000539.1/650534-650615 CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG ................(.(.......................)(......................)).............. ...(.(..........(.(.......................)(......................))..........).). ...(.(..((......(.(.......................)(......................))......).).).). >AM406670.1/4083393-4083321 CCUGCCGAGGAGCGCUGCGACCCGAAAUCACGCCGGGCCAGGCUCGGCAACCGAACAACGGCGCUCGCAAACC ................(.(..................)(..................)).............. ...(.(..........(.(...................)(.................))..........).). ...(.(..((......(.(...................)(.................))......).).).). >CP000555.1/3494432-3494509 ACUUUCGAGGAGCGUUGCAACUCCCGCCCGGGAGCCAGGCUCGAAAGUCAUCCCCCGAUGCAACGGCGCUCACCCGCA ................(.(.................)(.......................).).............. ....(.(.........(.(................)(.........................)).........).).. ....(.(.((......(.(................)(.........................))......).)).).. >CP000949.1/538083-537987 CUGUCCGAGGGGCGCUGCAGCAGGGUCAUCCUGUCAGGCUCGGAUGGGGCGUUGUCCGCUCCCGCGGACGCUCAACGCACAACGGCGCCCAUUCGCA ................(.(.........................).(................................)..).............. ...(.(..........(.(.........................).(................................)..)...........).) ...(.(..((......(.(.........................).(................................)..)......).)..).) >CP000304.1/4264519-4264605 CCACCCGAGGGGCGCUGCAGCAGGUUCCAGAACCUGUCAGGCUCGGAUGGGGCGUUUCCUCGAACGCAUCAACGGCGCCCAUUCGCA ................(.(..................)(...............................).).............. ...(.(..........(.(..................)(...............................).)...........).) ...(.(..((......(.(..................)(...............................).)......).)..).) >CP000113.1/8035799-8035872 GACUUCGAGGAGCGCUGCGAGGCCGGACCCGGCCCCAGGCUCGAAGCGGAAUCACCCAACGGCGCUCACCUGUA ...........(.(........................)(.......................))......... ....(.(.........(.(................)(....................).).........).).. ....(.(.((......(.(................)(....................).)......).)).).. >AL646052.1/107656-107582 AUUCCGAGGAGCGUUGCAACGGACCGGCAUCCGCCCGGCCGCCAGGCUCGGAAGUUCAAACGGCGCUCGCACUAU ...............(.(........................)(..............).).............. ..(.(..........(.(........................)(..............).).........).).. ..(.(..((......(.(........................)(..............).)......).)).).. >CP002271.1/7720690-7720757 CAACCUGAGGAGCGCUGCAACGGGGACUUCCCGCCAGGCUCAGGUUCAUGUAACGGCGCUCGCUGACU ................(.(........................)(.......)).............. ..(.(...........(.(........................)(.......))..........).). ..(.(...((......(.(........................)(.......))......).).).). >CP000089.1/57505-57435 UCUGCCGAGGAGCGCUGCGACCCUUUAAUUCGGGGGCCAGGCUCGGCAAUGAUCAACGGCGCUCGCAAACC ................(.(.................)(.................)).............. ...(.(..........(.(.................)(.................))...........).) ...(.(..((......(.(.................)(.................))......).)..).) >CP000352.1/177418-177491 CACUCCGAGGAGCGUUGCAACGGAUGGCCUCGCCUUCCGCCAGGCUCGGAAUGUUUCAACGGCGCUCGCAGUUC ................(.(.....................)(.............))................. ...(.(..........(.(.....................)(.............))..........).).... ...(.(..((......(.(.....................)(.............)).....).)..).).... >AATN01000007.1/46422-46509 GCCUGAGGAGCGCUGCAACGGUUAGCAGAUAUUAACUCGCUAACCGCUAGGCUCAGGCAAUCAUUUAGAUUAACUGCGCUCAUUCAAU ..............(.(.............................)(.......................).).............. .(.(..........(.(.............................)(.......................).)...........).) .(.(..((......(.(.............................)(.......................).)......).)..).) >AACY020581805.1/324-399 UCUUCCGAGGAGCGUUGCAACCGCCACUUUAGCUUGGCGGCCAGGCUCGGAACCGUGACAACGGCGCUCACCCGCA ................(.(.....................)(..................)).............. ...(.(..........(.(.....................)(..................))...........).) ...(.(..((......(.(.....................)(..................))......).)..).) >CP000680.1/478968-478877 CCGUCCGAGGGGCGCUGCAGCAGGUCGGUCGACACCGGUUUGUCAGGCUCGGAUGGGGCGUUAACCAUACGCAUCAACGGCGCCCAUUCGCA ................(.(........................).(............................)..).............. ...(.(..........(.(........................).(............................)..)...........).) ...(.(..((......(.(........................).(............................)..)......).)..).) >CP000116.1/2591667-2591597 GGUUCCGAGGAGCGCUGCGACGGUUCACCCGCCAGGCUCGGGACGCUUCCUUUCAACGGCGCUCACGUUUU ................(.(.................)(.................)).............. ...(.(..........(.(.............)(.....................)).........).).. ...(.(..((......(.(.............)(.....................))......).)).).. >CP000094.2/5940642-5940740 CUGUCCGAGGGGCGCUGCAGCAGGUUCAACCUGUCAGGCUCGGAUGGGGCGUUGACCGGCUCAGGCCGGACACUAAACGCACAACGGCGCCCAUUCGCA ................(.(.........................)(....................................).).............. ...(.(..........(.(.........................)(....................................).)...........).) ...(.(..((......(.(.........................)(....................................).)......).)..).) >AATN01006348.1/58-129 AAUCCGAGGAGCGCUGCAAGGCUGUCGUCCCACAGUUUCAGGCUCGGAUUCAUCAAACGGCGCUCAUCCCAC ...............(.(...................)(.................)).............. ..(.(..........(.(....................)....(............))..........).). ..(.(.(.(......(.(....................)....(............))......).).).). >CP001157.1/337304-337216 CCUUCCGAGGGGCGCUGCAGCAGGCCUGCCAACGGCCUGUCAGGCUCGGAAGGGGCGUUUUCCGAACGCAUCAACGGCGCCCAUUCGCA ................(.(..........................)...(......................).).............. ...(.(..........(.(..........................)...(......................).)...........).) ...(.(..((......(.(..........................)...(......................).)......).)..).) >AE015451.1/5667868-5667964 CUGUCCGAGGGGCGCUGCAGCAGGCUAGGCCUGUCAGGCUCGGAUGGGGCGUUGCUCGCUCCCGCGAGCGCUUAACGCACAACGGCGCCCAUUCGCA ................(.(.........................).(................................)..).............. ...(.(..........(.(........................)(....................................))...........).) ...(.(..((......(.(........................)(....................................))......).)..).) >AATO01002448.1/1018-1089 AAUCCGAGGGGCGCUGCAGGGCUGUCGUUCGACAGUUUCAGGCUCGGAUUUCUCAAACGGCGCUCAUCCAAC ...............(.(....................)(................)).............. ..(.(..........(.(....................)(................))..........).). ..(.(.(.(......(.(....................)(................))......).).).). >CT573326.1/5348242-5348337 CCGGCCGAGGGGCGCUGCAGCAGGUUCGUCCUGUCAGGCUCGGUCGGGGCGUUGUCCGCGCAGCGGACGCUCAACGCACAACGGCGCCCAUUCGCA ...................(.(........................).(...........................).)................. ....(.(............(.(........................).(...........................).)............).).. ....(.(.((......(.(....................)(.......................................))......).)).).. >AASZ01001430.1/3908-3830 CACCGAGGAGCGUUGCAACGGGACAAGGUCCCGCCAGGCUCGGUGAGGGCUCCAUAAGUUUCAACGGCGCUUACUCUGA ..............(.(..................)(......................)....).............. ..(.(.........(.(..................)(......................)....)..........).). >CP000453.1/2565212-2565295 CGCCCCGAGGAGCGCUGCAACAGGGCCGCCGGCCCUGCCAGGCUCGGGGAUGGCGCCCCAUCGUUCCAACGGCGCUCAGCGAAA ................(.(....................)(.........................)..).............. ...(.(..........(.(....................)(.........................)..)..........).). >CP000529.1/516171-516245 UCUCCUGAGGAGCGUUGCAACCCACGGCAUGUGGUCUAGGCUCAGGACUUCUAUUUGCAACCACGCUCACCCGCA ................(.(................................)(......)).............. ..(.(...........(.(................................)(......))...........).) >AE017282.2/144280-144199 GCGCCGAGGAGCGCUGCGACGGCCCGUCGAGGGCCGCCAGGCUCGGCGGGGACAAUCGGUUUUCCAACGGCGCUCUGUUUAU ...............(.(...................).(........................)..).............. ..(.(..........(.(...................).(........................)..)..........).). >AAUJ02000001.1/4967434-4967338 CCAUCCGAGGAGCGUUGCAGCGUUCCCCAGCCAGCCAUGAGCUGGCCUGCGCGGGGCGUGAGGCUCGGAUUUCAUCCCGCAACGACGCUCGCCCACG ................(.(.................................)(...........................)).............. ...(.(..........(.(.................................)(...........................)).......).).... >AAFX01122445.1/162-87 GCUUCGAGGAGCGCUGCGACUUGCGUGGUUUGCAAGCCAGGCUCGGAGCAUUCGACAGGAACGGCGCUCACCCACU ...............(.(............................)(............)).............. ..........(.(.........(.(................)(...........))........).)......... >CP001715.1/470000-469928 CAAUCCGAGGAGCGCUGCAGGGCCGUCGAUCGACGGUUUCAGGCUCGGAUUCCUUAAACGGCGCUCAUCCGAC ................(.(..................)(..................)).............. ....(.(.........(.(....................)(............)....).........).).. >CP000086.1/3610417-3610350 GUUUCCGAGGAGCGUUGCGACGGGCCCCGCCCGCCAGGCUCGGAAAUGGUCAACCGAGCGGUGUGUCU ................(.(........................)(............))......... ...(.(..........(.(...............).(.............))..........).)... >CP001111.1/740018-739937 CUGCCGAGGGGCGCUGCGACCGGAUCCCUUGAGGCCGGCCAGGCUCGGCCAGGUGGUACUGCAACAACGGCGCCCGGCCAGA ...............(.(.....................)(......................))................. ...(.(.........(.(.........)(..................................)).........).)..... >CP000267.1/475493-475563 UCUUCCAAGGAGCGUUGCAGUCGGCCACAUGGCCGGUCAGGCUUGGAUGACCCCAACGACGCUCACCUGAU ................(.(..................)(...............).).............. ...(.(..........(.(.........)(........................).)..........).). >CP000103.1/2909965-2909888 CAGACCGAGGAGCGCUGCAACGGGCAUUGUCCCGCGAGGCUCGGCAAGGAAGGAUCGCUACAACGGCGCUCGUUCAUU ................(.(........................).(................)).............. ...(.(..........(.(.........................)(................))..........).). >AATN01000007.1/45143-45222 ACUGAGGAGCGUUGCGACAGGUUUUCCUGCCAGGCUCAGUAGAUUGAAGGACAAUUUAAAUACAACGGCGCUCAGUCAUC .............(.(....................)(.........................).).............. (.(..........(.(....................)(.........................).)..........).). >CP000090.1/239471-239552 CACUCCGAGGAGCGUUGCAACGGAUCGUGGCGUAACAUGCCCUCCGCCAGGCUCGGACUGUCUUCAACGGCGCUCGCUGAUC ................(.(.....................................)(........)).............. >CP000542.1/736268-736181 CGCUCCGAGGAGCGUUGCAGCGCCUCCCACCGGCAGGGCCGGCGGGGCGUGAGGCUCGGGCAUCAUCUGGCAACGACGCUCAUCCACA ...................(.(.........................)(................))..................... >DQ996270.1/1772-1706 UUUCCGAGGAGCGUUGCGACGGGCACCGGCCCGCCAGGCUCGGAAAUCUUCACCAGGCGGUGGCCCG ..........(.(.................................)(..............))... >CP000450.1/2008790-2008713 UUGUACCGAGGAGCGCUGCAACGGUCUAUCUCGUGAGGCUCGGACAAAUGAACAACCCAACAACGGCGCUCUUUCACU .................(.(..............)(......................)....).............. >AASZ01000145.1/12763-12838 CCUGUGUGCGAGGAGCGCUGCGACAGCUUAACUGCCAGGCUCGCCCACUGGAUCAAUGCAACGGCGCUCGUAAAUA ...................(.(......................).(.............)).............. >AM260479.1/256130-256245 CACUCCGAGGAGCGUUGCAACGGAUGGAGGCCUGCGAAGCACAUCGCGCGGCCGGCGGCACAGCCGCCCCAUGCCAUCCGCCAGGCUCGGACUGUCUUCAACGGCGCUCGCUGAUC .................................(.(........)(..................................)).................................. >ABCT01000021.1/8794-8876 CCGUUCGAGGAGCGUUGCGACACACCCAUGCUUUUUUGGGGUGCUAGGCUCGAACAAGAAAUAAACAACGGCGCUCACGCUUC ................(.(........................)(......................)).............. >CP000884.1/6586554-6586470 CUCUCCGAGGAGCGUUGCAGCGGCCCCCACACAUCAGGCGUGGUCGCGAGGCUCGGAGUCAUACCUGCAACGACGCUCGCCCACG ...................(.(......................)(..........................))........... >CR555306.1/1088385-1088448 UGCCGAGGAGCGCUGCGAGACUUCCGUCCCAGGCUCGGCCCUUCAAAAACUGCGCUCACCUUAA .........(.(.....................).(.................))......... >AAFX01048275.1/188-258 CAUUAGCUGAGGAGCGCUGCAACUCCGGUUUACGGAACCAGGCUCAGCAAAUGAAACGGCGCUCGUUCCAA ..................(.(.................)(...............)).............. >CP000744.1/550599-550494 CCGUUCGAGGGGCGCUGCAGCAGGCCUAGGCCUGUCAGGCUCGAACGGAGCGCGCUCUCAGGCCGGCCUCGCCGGUCUGUCAACGCACCAACGGCGCCCAUUCGCA ................(.(.........................)...(.......................................)..)..............

	ORB			p-value	ORB frequency (per structure per nucleotide)	Means ratio
1	G(C(R)())			< 0.001		6.66

CP000539.1/650534-650615 CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG .........1.........2.........3.........4.........5.........6.........7.........8.. 1234567890123456789012345678901234567890123456789012345678901234567890123456789012
2	(C()N)			< 0.001		1.91

CP000539.1/650534-650615 CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG .........1.........2.........3.........4.........5.........6.........7.........8.. 1234567890123456789012345678901234567890123456789012345678901234567890123456789012
3	((C)R)Y			< 0.001		2.05

CP000539.1/650534-650615 CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG .........1.........2.........3.........4.........5.........6.........7.........8.. 1234567890123456789012345678901234567890123456789012345678901234567890123456789012
	ORB			p-value	ORB frequency (per structure per nucleotide)	Means ratio

	NCM			p-value	NCM frequency (per structure per nucleotide)	Means ratio
1	G(C(R))			< 0.001		3.97

CP000539.1/650534-650615 CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG .........1.........2.........3.........4.........5.........6.........7.........8.. 1234567890123456789012345678901234567890123456789012345678901234567890123456789012
2	.N.			< 0.001		1.29

CP000539.1/650534-650615 CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG CUUUCCGAGGAGCGUUGCAGCGUCCCCAGCACGGCGGGGCGCGAGGCUCGGAAGUCAUACCCAGCAACGACGCUCACCCACG .........1.........2.........3.........4.........5.........6.........7.........8.. 1234567890123456789012345678901234567890123456789012345678901234567890123456789012
	NCM			p-value	NCM frequency (per structure per nucleotide)	Means ratio

Structure is visualized using R2R 1.0.6 (Zasha Weinberg).
LOGOS are generated with ggseqlogo (Omar Wagih).