D-ORB

The Overrepresented RNA Blocks

M.J. Dupont, F. Major
D-ORB: A Web Server to Extract Structural Features of Related But Unaligned RNA Sequences
J. Mol. Biol., 435 (2023)

HOX antisense intergenic RNA myeloid 1 conserved region 4   (Rfam: RF01978)


Options
Negatives sequences: Random sequences of similar lengths
ORBs positions sequence: Best consensus structure-matching sequence
Motifs: 162,498 motifs on the alphabet ACGURYN
Rfam
D-ORB
Augmented

U(G(U))
C(YUR)G
U(RR(A))
(RA)
N(RG)A
U(UG)R

100.0
100.0
100.0
100.0
100.0
80.0

C(YUR)G
U(RR(A))
(RA)
N(RG)A
N(RG)A
U(UG)R

% of positive sequence with ORB






Deep neural network:

5-fold cross-validation: 99.9 %
(± 0.0299 %)

Decision tree:

5-fold cross-validation: 72.7 %
(± 15.8 %)

D-ORB structure
D-ORB structure decision tree:

5-fold cross-validation: 83.6 %
(± 11.3 %)
of AAPY01076957.1/2419-2520
AAPY01076957.1/2419-2520
GGGAUCAGAAUGUAGAUGUUUAAAACAAAUGUGUAUAAAUAAAUGAAUUGUUGGUAACUUAGUUAUUGACCUGAAGACUGUUAGCUUGUUAAAGAAACUCCA
(((((((...)).)(((((((..(((((((.(((((..)))))..)(.(((..))(((...)))))((((((((..)))))))))))))).)))))))))))
...................................................................................................1..
.........1.........2.........3.........4.........5.........6.........7.........8.........9.........0..
123456789012345678901234567890123456789012345678901234567890123456789012345678901234567890123456789012

abstract shape: (()(()()))

Number of sequences
Structure ORBs (out of 10) (%)
1 U(G(U))
9 90.0
>ACBE01077414.1/9750-9851
GGGGUUGGAAUGUAGAUGUUUGAAACAAAUGUGUAUAAAUAAAUGAAUUGUUGAUAACUUAGUUAUUGACCUGGAGACUGGUAGCUUGUUAAAGAAACUCCA
...............................(.(.....................)).............................................
>AAPY01076957.1/2419-2520
GGGAUCAGAAUGUAGAUGUUUAAAACAAAUGUGUAUAAAUAAAUGAAUUGUUGGUAACUUAGUUAUUGACCUGAAGACUGUUAGCUUGUUAAAGAAACUCCA
................(.(....................)).............................................................
>ABRQ01114923.1/3795-3894
GGGGCUGGAAUGUAGAUGUUUGAAAGAAACGUGUAAAUAAAUGAAUUGUGGAUAACUUAGUUAUUGGCCUGGAGACUAGUAGCUUGUUAAAGAAACUCCA
..........(.(.....................))................................................................
>AC004079.1/82251-82352
GGGGUUGAAAUGUGGGUGUUUGAAACAAAAGUGUAUAAACAAAUGAAUUGUUGAUAACUUAGUUAUUGACCUGGAGACUGGUAGCUUAUUAAAGAAACUCCG
................(.(....................)).............................................................
>AAKN02039089.1/9540-9640
GGGGUCGAAUGUAGAUGUUUCAGACAAACGUGUAUAAAUAAAUGAAUUGUUGGUAACUUAGUUAUUGACCUGGAGACUGAUAGCUUGUUCAAGAAACUCCA
..............................(.(.....................)).............................................
>AAIY01403574.1/1403-1504
GGGGUUGGAAUGUAGAUGUCUGAAACAAACGUGUAUAAAUAAAUGGAUUGCUGAUAACUUAGCUAUUGACCUGGAGACUAGUAGUUUGUUAAAGAAACCCCA
...............................(.(.....................)).............................................
>AAGW02035950.1/10379-10279
GGCUGGAAUGCAGAUGUUUGAAACAAAUGUGUAUUCAAUAAAUGAAUUGUUGAUAACUUAGUUAUUGGGCUGGAGACUGGUCGCUGGUCAGAGAAACGCCA
..............(.(.....................)).............................................................
>AAQQ01071857.1/581-671
GGGGUUGGAAUGUAGAUGUUUGGGACCAAUGUGUAUAAAUAAAUGAAUUGUUGAUAACUUAUUGACCUGGUAGCUUGUUAAAGAAACCCAG
...............................(.(.....................))..................................
>ABRO01036369.1/3733-3834
GGGGUUAAAAUGUAGAUGUUUGAAACAAAUGUGUAUAAAUAAAGGAAUUGUUGAUAACUUAGUUAAAAACAUGGAGACUAGCAGCUAGUUAAAGAAACUCCA
...............................(.(.....................)).............................................
2 U(G(U))
C(YUR)G
7 70.0
>AC004079.1/82251-82352
GGGGUUGAAAUGUGGGUGUUUGAAACAAAAGUGUAUAAACAAAUGAAUUGUUGAUAACUUAGUUAUUGACCUGGAGACUGGUAGCUUAUUAAAGAAACUCCG
................(.(....................))................(...)........................................
>AAQQ01071857.1/581-671
GGGGUUGGAAUGUAGAUGUUUGGGACCAAUGUGUAUAAAUAAAUGAAUUGUUGAUAACUUAUUGACCUGGUAGCUUGUUAAAGAAACCCAG
...............................(.(.....................))........(...).....................
>AAPY01076957.1/2419-2520
GGGAUCAGAAUGUAGAUGUUUAAAACAAAUGUGUAUAAAUAAAUGAAUUGUUGGUAACUUAGUUAUUGACCUGAAGACUGUUAGCUUGUUAAAGAAACUCCA
................(.(....................))................(...)........................................
>ACBE01077414.1/9750-9851
GGGGUUGGAAUGUAGAUGUUUGAAACAAAUGUGUAUAAAUAAAUGAAUUGUUGAUAACUUAGUUAUUGACCUGGAGACUGGUAGCUUGUUAAAGAAACUCCA
.............................(.(..........)..)...........(...)........................................
>AAIY01403574.1/1403-1504
GGGGUUGGAAUGUAGAUGUCUGAAACAAACGUGUAUAAAUAAAUGGAUUGCUGAUAACUUAGCUAUUGACCUGGAGACUAGUAGUUUGUUAAAGAAACCCCA
...............................(.(.....................))............(...)............................
>ABRQ01114923.1/3795-3894
GGGGCUGGAAUGUAGAUGUUUGAAAGAAACGUGUAAAUAAAUGAAUUGUGGAUAACUUAGUUAUUGGCCUGGAGACUAGUAGCUUGUUAAAGAAACUCCA
..........(.(.....................))...................(...)........................................
>AAGW02035950.1/10379-10279
GGCUGGAAUGCAGAUGUUUGAAACAAAUGUGUAUUCAAUAAAUGAAUUGUUGAUAACUUAGUUAUUGGGCUGGAGACUGGUCGCUGGUCAGAGAAACGCCA
..............(.(.....................))................(...)........................................
3 U(G(U))
C(YUR)G
U(RR(A))
6 60.0
>ABRQ01114923.1/3795-3894
GGGGCUGGAAUGUAGAUGUUUGAAAGAAACGUGUAAAUAAAUGAAUUGUGGAUAACUUAGUUAUUGGCCUGGAGACUAGUAGCUUGUUAAAGAAACUCCA
.....(..(.(.(.....................))...................(...)...............................).)......
>AC004079.1/82251-82352
GGGGUUGAAAUGUGGGUGUUUGAAACAAAAGUGUAUAAACAAAUGAAUUGUUGAUAACUUAGUUAUUGACCUGGAGACUGGUAGCUUAUUAAAGAAACUCCG
.....(..(.......(.(....................))................(...)................................))......
>AAQQ01071857.1/581-671
GGGGUUGGAAUGUAGAUGUUUGGGACCAAUGUGUAUAAAUAAAUGAAUUGUUGAUAACUUAUUGACCUGGUAGCUUGUUAAAGAAACCCAG
.....(..(.(.(.......................))...........................(...).............))......
>AAGW02035950.1/10379-10279
GGCUGGAAUGCAGAUGUUUGAAACAAAUGUGUAUUCAAUAAAUGAAUUGUUGAUAACUUAGUUAUUGGGCUGGAGACUGGUCGCUGGUCAGAGAAACGCCA
...(..(.......(.(........)).............................(...).................................)).....
>ACBE01077414.1/9750-9851
GGGGUUGGAAUGUAGAUGUUUGAAACAAAUGUGUAUAAAUAAAUGAAUUGUUGAUAACUUAGUUAUUGACCUGGAGACUGGUAGCUUGUUAAAGAAACUCCA
............(..(.............(.(..........)..)...........(...)...............................)).......
>AAPY01076957.1/2419-2520
GGGAUCAGAAUGUAGAUGUUUAAAACAAAUGUGUAUAAAUAAAUGAAUUGUUGGUAACUUAGUUAUUGACCUGAAGACUGUUAGCUUGUUAAAGAAACUCCA
....................(..(.....(.(..........)..)...........(...)...........................).)..........
4 U(G(U))
C(YUR)G
U(RR(A))
(RA)
5 50.0
>ABRQ01114923.1/3795-3894
GGGGCUGGAAUGUAGAUGUUUGAAAGAAACGUGUAAAUAAAUGAAUUGUGGAUAACUUAGUUAUUGGCCUGGAGACUAGUAGCUUGUUAAAGAAACUCCA
.....(..(.(.(........(..).........))...................(...)...............................).)......
>AC004079.1/82251-82352
GGGGUUGAAAUGUGGGUGUUUGAAACAAAAGUGUAUAAACAAAUGAAUUGUUGAUAACUUAGUUAUUGACCUGGAGACUGGUAGCUUAUUAAAGAAACUCCG
.....(..(.......(.(.......(..).........))................(...)................................))......
>AAGW02035950.1/10379-10279
GGCUGGAAUGCAGAUGUUUGAAACAAAUGUGUAUUCAAUAAAUGAAUUGUUGAUAACUUAGUUAUUGGGCUGGAGACUGGUCGCUGGUCAGAGAAACGCCA
...(..(.......(.(..(..)..)).............................(...).................................)).....
>ACBE01077414.1/9750-9851
GGGGUUGGAAUGUAGAUGUUUGAAACAAAUGUGUAUAAAUAAAUGAAUUGUUGAUAACUUAGUUAUUGACCUGGAGACUGGUAGCUUGUUAAAGAAACUCCA
............(..(.............(.(...(..)...)..)...........(...)...............................)).......
>AAPY01076957.1/2419-2520
GGGAUCAGAAUGUAGAUGUUUAAAACAAAUGUGUAUAAAUAAAUGAAUUGUUGGUAACUUAGUUAUUGACCUGAAGACUGUUAGCUUGUUAAAGAAACUCCA
....................(..(.....(.(...(..)...)..)...........(...)...........................).)..........
5 U(G(U))
C(YUR)G
U(RR(A))
(RA)
N(RG)A
4 40.0
>AAPY01076957.1/2419-2520
GGGAUCAGAAUGUAGAUGUUUAAAACAAAUGUGUAUAAAUAAAUGAAUUGUUGGUAACUUAGUUAUUGACCUGAAGACUGUUAGCUUGUUAAAGAAACUCCA
....................(..(.....(.(...(..)...)..)...........(...)...........(..)............).)..........
>AAGW02035950.1/10379-10279
GGCUGGAAUGCAGAUGUUUGAAACAAAUGUGUAUUCAAUAAAUGAAUUGUUGAUAACUUAGUUAUUGGGCUGGAGACUGGUCGCUGGUCAGAGAAACGCCA
...(..(.......(.(..(..)..)).............................(...)...........(..)..................)).....
>ACBE01077414.1/9750-9851
GGGGUUGGAAUGUAGAUGUUUGAAACAAAUGUGUAUAAAUAAAUGAAUUGUUGAUAACUUAGUUAUUGACCUGGAGACUGGUAGCUUGUUAAAGAAACUCCA
............(..(.............(.(...(..)...)..)...........(...)...........(..)................)).......
>AC004079.1/82251-82352
GGGGUUGAAAUGUGGGUGUUUGAAACAAAAGUGUAUAAACAAAUGAAUUGUUGAUAACUUAGUUAUUGACCUGGAGACUGGUAGCUUAUUAAAGAAACUCCG
.....(..(.......(.(.......(..).........))................(...)...........(..).................))......
6 U(G(U))
C(YUR)G
U(RR(A))
(RA)
N(RG)A
U(UG)R
4 40.0
>AAPY01076957.1/2419-2520
GGGAUCAGAAUGUAGAUGUUUAAAACAAAUGUGUAUAAAUAAAUGAAUUGUUGGUAACUUAGUUAUUGACCUGAAGACUGUUAGCUUGUUAAAGAAACUCCA
....................(..(.....(.(...(..)...)..)....(..)...(...)...........(..)............).)..........
>ACBE01077414.1/9750-9851
GGGGUUGGAAUGUAGAUGUUUGAAACAAAUGUGUAUAAAUAAAUGAAUUGUUGAUAACUUAGUUAUUGACCUGGAGACUGGUAGCUUGUUAAAGAAACUCCA
............(..(.............(.(...(..)...)..)....(..)...(...)...........(..)................)).......
>AAGW02035950.1/10379-10279
GGCUGGAAUGCAGAUGUUUGAAACAAAUGUGUAUUCAAUAAAUGAAUUGUUGAUAACUUAGUUAUUGGGCUGGAGACUGGUCGCUGGUCAGAGAAACGCCA
...(..(.......(.(..(..)..))......................(..)...(...)...........(..)..................)).....
>AC004079.1/82251-82352
GGGGUUGAAAUGUGGGUGUUUGAAACAAAAGUGUAUAAACAAAUGAAUUGUUGAUAACUUAGUUAUUGACCUGGAGACUGGUAGCUUAUUAAAGAAACUCCG
.....(..(.......(.(.......(..).........)).........(..)...(...)...........(..).................))......

>ACBE01077414.1/9750-9851
GGGGUUGGAAUGUAGAUGUUUGAAACAAAUGUGUAUAAAUAAAUGAAUUGUUGAUAACUUAGUUAUUGACCUGGAGACUGGUAGCUUGUUAAAGAAACUCCA
...............................(.(.....................)).............................................
.............................(.(..........)..)...........(...)........................................
............(..(.............(.(..........)..)...........(...)...............................)).......
............(..(.............(.(...(..)...)..)...........(...)...............................)).......
............(..(.............(.(...(..)...)..)...........(...)...........(..)................)).......
............(..(.............(.(...(..)...)..)....(..)...(...)...........(..)................)).......
>AAPY01076957.1/2419-2520
GGGAUCAGAAUGUAGAUGUUUAAAACAAAUGUGUAUAAAUAAAUGAAUUGUUGGUAACUUAGUUAUUGACCUGAAGACUGUUAGCUUGUUAAAGAAACUCCA
................(.(....................)).............................................................
................(.(....................))................(...)........................................
....................(..(.....(.(..........)..)...........(...)...........................).)..........
....................(..(.....(.(...(..)...)..)...........(...)...........................).)..........
....................(..(.....(.(...(..)...)..)...........(...)...........(..)............).)..........
....................(..(.....(.(...(..)...)..)....(..)...(...)...........(..)............).)..........
>AC004079.1/82251-82352
GGGGUUGAAAUGUGGGUGUUUGAAACAAAAGUGUAUAAACAAAUGAAUUGUUGAUAACUUAGUUAUUGACCUGGAGACUGGUAGCUUAUUAAAGAAACUCCG
................(.(....................)).............................................................
................(.(....................))................(...)........................................
.....(..(.......(.(....................))................(...)................................))......
.....(..(.......(.(.......(..).........))................(...)................................))......
.....(..(.......(.(.......(..).........))................(...)...........(..).................))......
.....(..(.......(.(.......(..).........)).........(..)...(...)...........(..).................))......
>AAGW02035950.1/10379-10279
GGCUGGAAUGCAGAUGUUUGAAACAAAUGUGUAUUCAAUAAAUGAAUUGUUGAUAACUUAGUUAUUGGGCUGGAGACUGGUCGCUGGUCAGAGAAACGCCA
..............(.(.....................)).............................................................
..............(.(.....................))................(...)........................................
...(..(.......(.(........)).............................(...).................................)).....
...(..(.......(.(..(..)..)).............................(...).................................)).....
...(..(.......(.(..(..)..)).............................(...)...........(..)..................)).....
...(..(.......(.(..(..)..))......................(..)...(...)...........(..)..................)).....
>ABRQ01114923.1/3795-3894
GGGGCUGGAAUGUAGAUGUUUGAAAGAAACGUGUAAAUAAAUGAAUUGUGGAUAACUUAGUUAUUGGCCUGGAGACUAGUAGCUUGUUAAAGAAACUCCA
..........(.(.....................))................................................................
..........(.(.....................))...................(...)........................................
.....(..(.(.(.....................))...................(...)...............................).)......
.....(..(.(.(........(..).........))...................(...)...............................).)......
>AAQQ01071857.1/581-671
GGGGUUGGAAUGUAGAUGUUUGGGACCAAUGUGUAUAAAUAAAUGAAUUGUUGAUAACUUAUUGACCUGGUAGCUUGUUAAAGAAACCCAG
...............................(.(.....................))..................................
...............................(.(.....................))........(...).....................
.....(..(.(.(.......................))...........................(...).............))......
>AAIY01403574.1/1403-1504
GGGGUUGGAAUGUAGAUGUCUGAAACAAACGUGUAUAAAUAAAUGGAUUGCUGAUAACUUAGCUAUUGACCUGGAGACUAGUAGUUUGUUAAAGAAACCCCA
...............................(.(.....................)).............................................
...............................(.(.....................))............(...)............................
>AAKN02039089.1/9540-9640
GGGGUCGAAUGUAGAUGUUUCAGACAAACGUGUAUAAAUAAAUGAAUUGUUGGUAACUUAGUUAUUGACCUGGAGACUGAUAGCUUGUUCAAGAAACUCCA
..............................(.(.....................)).............................................
>ABRO01036369.1/3733-3834
GGGGUUAAAAUGUAGAUGUUUGAAACAAAUGUGUAUAAAUAAAGGAAUUGUUGAUAACUUAGUUAAAAACAUGGAGACUAGCAGCUAGUUAAAGAAACUCCA
...............................(.(.....................)).............................................

ORB p-value ORB frequency
(per structure per nucleotide)
Means
ratio
1 U(G(U)) < 0.001 10.7
AAPY01076957.1/2419-2520
GGGAUCAGAAUGUAGAUGUUUAAAACAAAUGUGUAUAAAUAAAUGAAUUGUUGGUAACUUAGUUAUUGACCUGAAGACUGUUAGCUUGUUAAAGAAACUCCA
GGGAUCAGAAUGUAGAUGUUUAAAACAAAUGUGUAUAAAUAAAUGAAUUGUUGGUAACUUAGUUAUUGACCUGAAGACUGUUAGCUUGUUAAAGAAACUCCA
GGGAUCAGAAUGUAGAUGUUUAAAACAAAUGUGUAUAAAUAAAUGAAUUGUUGGUAACUUAGUUAUUGACCUGAAGACUGUUAGCUUGUUAAAGAAACUCCA
GGGAUCAGAAUGUAGAUGUUUAAAACAAAUGUGUAUAAAUAAAUGAAUUGUUGGUAACUUAGUUAUUGACCUGAAGACUGUUAGCUUGUUAAAGAAACUCCA
GGGAUCAGAAUGUAGAUGUUUAAAACAAAUGUGUAUAAAUAAAUGAAUUGUUGGUAACUUAGUUAUUGACCUGAAGACUGUUAGCUUGUUAAAGAAACUCCA
GGGAUCAGAAUGUAGAUGUUUAAAACAAAUGUGUAUAAAUAAAUGAAUUGUUGGUAACUUAGUUAUUGACCUGAAGACUGUUAGCUUGUUAAAGAAACUCCA
...................................................................................................1..
.........1.........2.........3.........4.........5.........6.........7.........8.........9.........0..
123456789012345678901234567890123456789012345678901234567890123456789012345678901234567890123456789012
2 C(YUR)G < 0.001 11.9
AAPY01076957.1/2419-2520
GGGAUCAGAAUGUAGAUGUUUAAAACAAAUGUGUAUAAAUAAAUGAAUUGUUGGUAACUUAGUUAUUGACCUGAAGACUGUUAGCUUGUUAAAGAAACUCCA
...................................................................................................1..
.........1.........2.........3.........4.........5.........6.........7.........8.........9.........0..
123456789012345678901234567890123456789012345678901234567890123456789012345678901234567890123456789012
3 U(RR(A)) < 0.001 1.35
AAPY01076957.1/2419-2520
GGGAUCAGAAUGUAGAUGUUUAAAACAAAUGUGUAUAAAUAAAUGAAUUGUUGGUAACUUAGUUAUUGACCUGAAGACUGUUAGCUUGUUAAAGAAACUCCA
GGGAUCAGAAUGUAGAUGUUUAAAACAAAUGUGUAUAAAUAAAUGAAUUGUUGGUAACUUAGUUAUUGACCUGAAGACUGUUAGCUUGUUAAAGAAACUCCA
GGGAUCAGAAUGUAGAUGUUUAAAACAAAUGUGUAUAAAUAAAUGAAUUGUUGGUAACUUAGUUAUUGACCUGAAGACUGUUAGCUUGUUAAAGAAACUCCA
GGGAUCAGAAUGUAGAUGUUUAAAACAAAUGUGUAUAAAUAAAUGAAUUGUUGGUAACUUAGUUAUUGACCUGAAGACUGUUAGCUUGUUAAAGAAACUCCA
GGGAUCAGAAUGUAGAUGUUUAAAACAAAUGUGUAUAAAUAAAUGAAUUGUUGGUAACUUAGUUAUUGACCUGAAGACUGUUAGCUUGUUAAAGAAACUCCA
GGGAUCAGAAUGUAGAUGUUUAAAACAAAUGUGUAUAAAUAAAUGAAUUGUUGGUAACUUAGUUAUUGACCUGAAGACUGUUAGCUUGUUAAAGAAACUCCA
...................................................................................................1..
.........1.........2.........3.........4.........5.........6.........7.........8.........9.........0..
123456789012345678901234567890123456789012345678901234567890123456789012345678901234567890123456789012
4 N(RG)A < 0.001 5.8
AAPY01076957.1/2419-2520
GGGAUCAGAAUGUAGAUGUUUAAAACAAAUGUGUAUAAAUAAAUGAAUUGUUGGUAACUUAGUUAUUGACCUGAAGACUGUUAGCUUGUUAAAGAAACUCCA
GGGAUCAGAAUGUAGAUGUUUAAAACAAAUGUGUAUAAAUAAAUGAAUUGUUGGUAACUUAGUUAUUGACCUGAAGACUGUUAGCUUGUUAAAGAAACUCCA
...................................................................................................1..
.........1.........2.........3.........4.........5.........6.........7.........8.........9.........0..
123456789012345678901234567890123456789012345678901234567890123456789012345678901234567890123456789012
5 U(UG)R < 0.001 9.45
AAPY01076957.1/2419-2520
GGGAUCAGAAUGUAGAUGUUUAAAACAAAUGUGUAUAAAUAAAUGAAUUGUUGGUAACUUAGUUAUUGACCUGAAGACUGUUAGCUUGUUAAAGAAACUCCA
...................................................................................................1..
.........1.........2.........3.........4.........5.........6.........7.........8.........9.........0..
123456789012345678901234567890123456789012345678901234567890123456789012345678901234567890123456789012
6 (RA) 0.00193 2.28
AAPY01076957.1/2419-2520
GGGAUCAGAAUGUAGAUGUUUAAAACAAAUGUGUAUAAAUAAAUGAAUUGUUGGUAACUUAGUUAUUGACCUGAAGACUGUUAGCUUGUUAAAGAAACUCCA
GGGAUCAGAAUGUAGAUGUUUAAAACAAAUGUGUAUAAAUAAAUGAAUUGUUGGUAACUUAGUUAUUGACCUGAAGACUGUUAGCUUGUUAAAGAAACUCCA
GGGAUCAGAAUGUAGAUGUUUAAAACAAAUGUGUAUAAAUAAAUGAAUUGUUGGUAACUUAGUUAUUGACCUGAAGACUGUUAGCUUGUUAAAGAAACUCCA
...................................................................................................1..
.........1.........2.........3.........4.........5.........6.........7.........8.........9.........0..
123456789012345678901234567890123456789012345678901234567890123456789012345678901234567890123456789012
ORB p-value ORB frequency
(per structure per nucleotide)
Means
ratio

NCM p-value NCM frequency
(per structure per nucleotide)
Means
ratio
1 .AUGNA. < 0.001 27.8
NCM p-value NCM frequency
(per structure per nucleotide)
Means
ratio

Structure is visualized using R2R 1.0.6 (Zasha Weinberg).
LOGOS are generated with ggseqlogo (Omar Wagih).